Sweden, Oct. 18 -- Project Id: 75644
Description: Grant agreement ID: 681893
Status
Ongoing project
Start date
1 September 2016
End date
31 August 2021
Funded under:
H2020-EU.1.1.
Overall budget:
€ 1 895 155
EU contribution
€ 1 895 155
Objective
Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process that is defective in multiple sclerosis (MS). Although OL precursor cells (OPCs) can initially promote remyelination in MS, this regenerative mechanism eventually fails in progressive MS. OPCs go through several epigenetic states that ultimately define their potential to differentiate and myelinate. OPCs in progressive MS stall in a distinct epigenetic state, incompatible with differentiat...