Sweden, Oct. 18 -- Project Id: 75644

Description: Grant agreement ID: 681893


Ongoing project

Start date

1 September 2016

End date

31 August 2021

Funded under:


Overall budget:

€ 1 895 155

EU contribution

€ 1 895 155


Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process that is defective in multiple sclerosis (MS). Although OL precursor cells (OPCs) can initially promote remyelination in MS, this regenerative mechanism eventually fails in progressive MS. OPCs go through several epigenetic states that ultimately define their potential to differentiate and myelinate. OPCs in progressive MS stall in a distinct epigenetic state, incompatible with differentiat...