India, Dec. 23 -- This week, the Indianapolis Colts (8-6) will host Monday Night Football for the first time since 2022 when they take on the San Francisco 49ers (10-4) at Lucas Oil Stadium.

While some prominent players will be absent from the primetime match, others are still questionable. Injuries to important offensive and defensive players might affect how the game plays out with playoff implications on the line.

The San Francisco 49ers will be without wide receiver Ricky Pearsall, who has been officially ruled out due to a knee and ankle injury suffered in last week's game against the Tennessee Titans.

Pearsall did not practice all week and failed to clear the final hurdle for Monday night's game.

Head coach Kyle Shanahan said af...