International Clinical Trial: Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma: A Multicenter, Open-label, Randomized, Phase III Clinical Study

Geneva, Jan. 12 -- International Clinical Trials Registry received information related to the study (ChiCTR2500115666) titled 'Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma: A Multicenter, Open-label, Randomized, Phase III Clinical Study' on Dec. 30, 2025.

Study Type: Interventional study

Study Design: Parallel

Primary Sponsor: Sun Yat-sen Memorial Hospital,Sun Yat-sen University

Condition: Locally advanced oral squamous cell carcinoma

Intervention: Control arm:Radical surgery combined with radiotherapy or chemoradiotherapy Experimental arm:Neoadjuvant sintilimab combined with TP regimen followed by radical surgery and risk-stratified adjuvant therapy (low-risk...