U.S., Jan. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07330869) titled 'Warfarin Effects on Male Fertility After Cardiac Surgery' on Dec. 15, 2025.
Brief Summary: Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair or bioprosthetic valve implantation. Although the teratogenic effects of warfarin during pregnancy are well established, prospective clinical data on the potential impact of warfarin therapy on male reproductive health are scarce. This gap is particularly relevant for patients of reproductive age who may have a present...