U.S., Dec. 2 -- ClinicalTrials.gov registry received information related to the study (NCT07256418) titled 'Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma' on Nov. 20.
Brief Summary: Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fib...