Clinical Trial: Tofersen in Non-SOD1 ALS

U.S., Dec. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07294144) titled 'Tofersen in Non-SOD1 ALS' on Dec. 15.

Brief Summary: The goal of this clinical trial is to evaluate whether tofersen is safe and effective in adults with non-SOD1 ALS. Tofersen is currently approved by the U.S. Food and Drug Administration to treat SOD1-ALS. The main questions it aims to answer are:

* Does tofersen lower the levels of neurofilament light chain (NfL) in the blood and CSF of adult participants with non-SOD1 ALS?

* Is tofersen safe and tolerable for adult participants with non-SOD1 ALS?

* Does tofersen affect other measurements such as clinical outcomes and quality-of-life measures in participants with non-SOD1 ALS?...