U.S., March 20 -- ClinicalTrials.gov registry received information related to the study (NCT06883214) titled 'Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application' on March 12.
Brief Summary: Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, bu...