U.S., April 2 -- ClinicalTrials.gov registry received information related to the study (NCT06904716) titled 'The Study of Transcranial Magnetic Stimulation in the Regulation of Spinocerebellar Ataxia' on March 11.
Brief Summary: Spinocerebellar ataxia (SCA) is a group of hereditary neurological diseases caused by gene mutations leading to degenerative changes in the cerebellum, brainstem, and spinal cord. A key pathogenic mechanism of SCA is the repeated expansion of cytosine - adenine - guanine (CAG) trinucleotides in the coding region of specific genes. These repeated expansions are translated into abnormally large polyglutamine (PolyQ) tracts in proteins. These polyglutamine (PolyQ) tracts can cause changes in the excitability of the ce...