Clinical Trial: The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study

U.S., Jan. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07319884) titled 'The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study' on Dec. 20, 2025.

Brief Summary: aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy

Design Details: Each participant will have one side of the mouth assigned to the fluoride varnish intervention, while the contralateral side will serve as the control without fluoride varnish.

Outcomes:

Primary outcome: Incidence and Severity of White Spot Lesions Measured before and after six months using Laser fl...