U.S., Aug. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07132606) titled 'The Predictive Value of Serum Histone Succinylation in Malignant Solid Tumors' on July 15.
Brief Summary: In recent years, advances in protein post-translational modification (PTM) research have revealed histone succinylation as a novel epigenetic modification mechanism critically involved in tumor initiation, progression, and prognosis. Succinylation alters protein physicochemical properties and functions, thereby modulating cellular metabolism, proliferation, and apoptosis. Aberrant histone succinylation in tumor cells demonstrates significant correlations with tumor type, staging, and clinical outcomes, offering new avenues for e...