U.S., Dec. 13 -- ClinicalTrials.gov registry received information related to the study (NCT07278453) titled 'TB SCReening Improves Preventive Therapy Uptake in Pregnant Women With HIV' on Dec. 02.
Brief Summary: Because pregnant women have been excluded from clinical research, including tuberculosis (TB) research, little is known about diagnosing, treating and preventing TB in pregnant women. We plan to perform a two-stage randomized trial that will identify best practices for screening pregnant and postpartum women for active TB (screening by symptoms vs. C-reactive protein levels) and the optimal timing of TPT initiation, relative to pregnancy (immediately during pregnancy or deferred to postpartum). Because undiagnosed TB among pregnant...