U.S., Feb. 4 -- ClinicalTrials.gov registry received information related to the study (NCT07383779) titled 'Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus' on Dec. 05, 2025.
Brief Summary: The HYBERNATUS-II study is a phase-III, open-label, randomized controlled trial in patients with convulsive refractory SE receiving mechanical ventilation. Patients are allocated at random to either early targeted hypothermia for 24 hours or targeted normothermia at the acute phase of ICU management. This trial is a superiority multicentric trial and patients will be randomized in a 1:1 ratio using an electronic Cas Report Form.
Before any examination or intervention related to the study may be carried o...