U.S., May 21 -- ClinicalTrials.gov registry received information related to the study (NCT06979440) titled 'Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression' on May 13.
Brief Summary: The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence. Our preliminary experiments identified 5-AVAB, a gut microbiota-derived metabolite, as a potential novel biomarker for T2DD progression. Given the absence of existing research in this area, it warrants in-depth investigation.
We plan to collect fecal and serum samples from patients with type 2 diabetes and those with T2DD to quantify 5-AVAB ...