U.S., April 5 -- ClinicalTrials.gov registry received information related to the study (NCT06910527) titled 'Study of the Plasma and Urinary cfDNA of in Kidney Transplant Patients' on March 19.
Brief Summary: It has been shown that the amount of circulating donor-cell-free DNA increases in patients with transplant rejection. Quantification of single nucleotide polymorphisms (SNPs) present in circulating donor DNA currently allows for early identification of transplant rejection, but not for characterization, i.e., identification of the affected renal fraction of the graft.
Recently, in healthy subjects, teams have shown that it is possible to identify the tissue origin of donor-cell-free DNA, based on the epigenetic properties of circulat...