U.S., March 11 -- ClinicalTrials.gov registry received information related to the study (NCT06867549) titled 'Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II' on Feb. 25.
Brief Summary: The investigators hypothesize that brief behavioral therapy and targeted propofol infusion in depressed geriatric patients will augment subsequent slow wave sleep and improve clinical and cognitive outcomes. The team will recruit 70 participants for a double-blinded placebo controlled randomized controlled trial. Two propofol infusions, 2-6 days apart, will be administered, targeting either a low propofol dose arm (minimal EEG slow waves, brain effect-site concentration 1-2 mcg/ml) or moderate dose propofol arm (maximal induction o...