U.S., Feb. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07387120) titled 'Sertraline and the Risk of Serious Adverse Events' on Jan. 28.
Brief Summary: The goal of this population-based cohort study is to assess the safety of initiating a new outpatient prescription of 50 mg/day of Sertraline, a higher dose, compared to 25 mg/day, a lower dose, in adults aged 65+ with low kidney function. The primary question is whether initiating a new outpatient prescription of a higher dose of Sertraline (50mg/day) compared to a lower dose (25 mg/day) in older adults with low kidney function (an eGFR <45 mL/min per 1.73 m2, but not receiving dialysis or having a history of kidney transplantation) is associated with a hi...