Clinical Trial: S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture

U.S., Nov. 25 -- ClinicalTrials.gov registry received information related to the study (NCT04643132) titled 'S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture' on Nov. 17.

Brief Summary: Purpose:

To explore effects of S-ketamine on postoperative pain and cognitive dysfunction after tibial fracture and orthopedic surgery.

To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose.

Study Type: Interventional

Condition: * Postoperative Pain

* Postoperative Cognitive Dysfunction

Intervention: * Drug: Normal saline

After the induction of anesthesia, normal saline is intravenously injected in a volume of 2ml, and then a continuous infusion of 20ml/h normal s...