U.S., Jan. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07319026) titled 'Role of Myeloid-derived Suppressor Cells In Primary Myelofibrosis' on Nov. 20, 2025.
Brief Summary: The goals of this observational study are to investigate the role of myeloid-derived suppressor cells (MDSCs) in fueling chronic inflammation that is a relevant pathogenetic mechanism in patients with primary myelofibrosis (PMF), to study modifications in MDSC phenotype and function after treatment with JAK-inhibitors (JAK-i) and to test their participation in the neoangiogenic process. The main questions it aims to answer are:
* Do the frequency and function of MDSCs contribute to induce or sustain the inflammatory status that charac...