U.S., Sept. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07161336) titled 'Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA' on Aug. 30.
Brief Summary: Background:
Osteoarthritis (OA) is a leading cause of disability worldwide, with limited treatment options and many patients suffering from chronic pain. Modern imaging has revealed that OA involves complex changes in cartilage, subchondral bone, and synovium. Pain in OA is often linked to synovitis, which is common in the condition. Methotrexate (MTX), a proven treatment for synovitis in inflammatory arthritis like rheumatoid arthritis and has a well-known safety profile. The proposal suggests that using MTX may have potential to tre...