U.S., June 4 -- ClinicalTrials.gov registry received information related to the study (NCT07000890) titled 'Rheumatoid Arthritis Synovial Tissue Biopsy Study' on June 20, 2022.
Brief Summary: In this proof-of-concept study, the investigators intend to collect synovial biopsies from MTX-resistant RA patients prior to and 12 weeks after initiation of TNF-blocking therapy (period 1). In addition to conventional histological and immunohistochemistry characterization of the samples, single cell RNASeq studies will be performed, with a particular focus on synovial T cells and fibroblasts. Clinical response to TNF blocking therapies will be assessed using validated measurements, which will result in the identification of novel mechanisms and mark...