Clinical Trial: Protein A Immunoadsorption in Highly Sensitized Haplo-HSCT Patients

U.S., Oct. 2 -- ClinicalTrials.gov registry received information related to the study (NCT07200583) titled 'Protein A Immunoadsorption in Highly Sensitized Haplo-HSCT Patients' on Sept. 23.

Brief Summary: This study reviews patients who received haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Some patients develop donor-specific antibodies (DSA), which can block engraftment and cause transplant failure. Before transplant, a treatment called protein A immunoadsorption (a blood purification method to remove antibodies) was used, sometimes with additional medications.

The study aims to see whether this approach lowers antibody levels, increases the chance of successful engraftment, reduces complications such as infection...