U.S., March 7 -- ClinicalTrials.gov registry received information related to the study (NCT06862349) titled 'Propofol Induction Based on Lean Body Weight on the Depth of Anesthesia' on March 03.
Brief Summary: Propofol has significant hemodynamic side effects. It is a lipophilic agent and is generally used at a dose of 2-2.5 mg/kg for induction. In patients with a body mass index (BMI) greater than 25, it can lead to serious complications. This patient group often has comorbidities such as hypertension, coronary artery disease, left ventricular hypertrophy, stroke, and obstructive sleep apnea.
Hemodynamic profile changes are influenced by both the rate of propofol administration and the total dose. Therefore, it is necessary to investigat...