U.S., April 12 -- ClinicalTrials.gov registry received information related to the study (NCT06923670) titled 'Prevalence Of Germline Gene Mutations In Patients With Myeloproliferative Neoplasms With Family History' on March 26.
Brief Summary: Philadelphia-negative myeloproliferative neoplasms (MPNs) occur sporadically and are due to somatic mutations in the JAK2 (Janus kinase 2), CALR (calreticulin) and MPL (thrombopoietin receptor) genes. However, data from epidemiological and family studies clearly highlight a heritable component that influences the risk of developing MPN and potentially contributes to the observed phenotypic pleiotropy. Genome-wide association studies in MPN familial clusters have identified a number of germline genetic...