U.S., Oct. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07220382) titled 'Preoperative BOTOX(R) Injection for Large Ventral Hernia Repair' on Oct. 17.
Brief Summary: This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. We are testing whether a one-time, image-guided injection of a medicine commonly known as "BOTOX(R)" (onabotulinumtoxinA) into the side abdominal muscles 3-7 weeks before surgery helps surgeons close the abdominal wall fully at the end of the operation. Closing the muscle and tissue layers ("primary fascial closure") is linked to fewer problems after surgery and better quality of life.
Participants will be randomly assigned (like a coin flip) to...