U.S., July 18 -- ClinicalTrials.gov registry received information related to the study (NCT07070102) titled 'Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children' on June 23.
Brief Summary: Temocillin, a 6-alpha-methoxypenicillin derivative of ticarcillin, is a narrow-spectrum antibiotic, primarily restricted to Enterobacterales. Therefore, its prescription for the treatment of febrile urinary tract infections requiring hospitalization in pediatrics appears interesting.
However, and despite marketing authorization in pediatrics for the treatment of complicated urinary tract infections (including acute pyelonephritis), the pharmacokinetic parameters of this antibiotic have not been specifically eval...