Clinical Trial: Plasma and Tissue Concentration of Cefazolin in Preoperative Prophylaxis in Patients Undergoing Bariatric Surgery

U.S., Nov. 29 -- ClinicalTrials.gov registry received information related to the study (NCT07253805) titled 'Plasma and Tissue Concentration of Cefazolin in Preoperative Prophylaxis in Patients Undergoing Bariatric Surgery' on Nov. 13.

Brief Summary: This study investigates whether current cefazolin dosing guidelines for obese patients-2 g IV for those =120 kg-achieve adequate plasma and tissue concentrations (>=8 mg/L) for effective surgical prophylaxis. While several retrospective and prospective studies suggest that a 2 g dose may be sufficient regardless of weight, findings are inconsistent and often rely solely on plasma concentrations. Given that tissue concentration at the site of action is a more relevant pharmacokinetic marker, th...