U.S., March 21 -- ClinicalTrials.gov registry received information related to the study (NCT06887881) titled 'PIMS Vs PGT-A in Infertile PCOS Patients' on Jan. 25, 2024.
Brief Summary: This experiment has become a serious issue for two reasons: DNA methylation plays an important role during embryogenesis, global abnormal methylome reprogramming often occurs in human embryos, and DNA methylome pattern is associated with live birth rate. The endocrine metabolic disorders of polycystic ovarian syndrome (PCOS) patients may affect the epigenetic status of embryos and lead to the decrease of live birth rate in PCOS patients. However, there is still no technology using DNA methylome as an indicator in preimplantation embryo screening in PCOS pati...