Clinical Trial: Phase 3 Trial Comparing IMRT or IMPT Plus CIRT for Patients with Locally Advanced NPC

U.S., Feb. 27 -- ClinicalTrials.gov registry received information related to the study (NCT06846450) titled 'Phase 3 Trial Comparing IMRT or IMPT Plus CIRT for Patients with Locally Advanced NPC' on Feb. 17.

Brief Summary: The goal of this phase 3 non-inferiority trial is to compare the efficacy and toxicity of proton or photon radiation therapy plus carbon ion radiation therapy for newly diagnosed nasopharyngeal carcinoma. The main question it aims to answer is that if proton radiation therapy plus carbon ion radiation therapy is non-inferior to photon radiation therapy plus carbon ion radiation therapy in terms of therapeutic efficacy. Participants will be randomized to receive either proton radiation therapy (arm 1) or photon radiation ...