U.S., Dec. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07262736) titled 'Pharmacokinetics of Clozapine and Norclozapine and the Effect of Pantoprazole' on Nov. 19.
Brief Summary: Clozapine is an effective treatment for patients with schizophrenia who do not respond to other therapies, but its blood concentration varies widely between individuals due to genetic and physiological differences. Proton pump inhibitors such as pantoprazole are often prescribed in this population to prevent stomach discomfort, yet their impact on clozapine exposure has not been fully characterized. This clinical study will investigate the pharmacokinetics of clozapine and its main metabolite norclozapine, the influence of indivi...