U.S., Jan. 28 -- ClinicalTrials.gov registry received information related to the study (NCT06795100) titled 'Pharmacokinetic Study of Intravenous Lidocaine in Young and Elderly Patients' on Dec. 13, 2024.
Brief Summary: Aging is accompanied by a gradual alteration in the functional reserve of several organs and a change in body composition that can affect the pharmacokinetics, response, and safety profile of medications. Lidocaine is a local anesthetic used daily in perineural or intravenous administration to reduce the need for opioids. Although its analgesic efficacy is well-established, there is currently only one older study regarding the pharmacokinetics and pharmacokinetic-pharmacodynamic (PK-PD) relationship of lidocaine in healthy ...