U.S., June 12 -- ClinicalTrials.gov registry received information related to the study (NCT07015060) titled 'Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis' on May 22.
Brief Summary: Identify rare variants in candidate genes and pathways identified in familial SSc, in patients with sporadic SSc.
Perform (spatial) transcriptomic and proteomic analyses of affected skin from patients with and without cutaneous fibrosis, for the patterns and levels of expression/activation of candidate genes and pathways.
Test for dysregulation of expression/activation of candidate genes and pathways in live cells isolated from the blood and skin biopsy of patients, and for the impact of these dysregulations on cell ap...