U.S., Feb. 13 -- ClinicalTrials.gov registry received information related to the study (NCT06822465) titled 'Pathobiomes in Gut of Critically Ill Patients' on Jan. 28.
Brief Summary: Despite powerful antibiotics, 50% of the intestinal tracts of critically ill surgical patients are colonized by Pseudomonas aeruginosa, whose mere presence in this site increases mortality fourfold by mechanisms that remain unknown. Many patients who survive the initial surgical trauma still succumb to multi-organ failure and septicemia secondary to an invasive nosocomial infection. The sequelae of shock, hypoxia, and parental nutrition result in injury to the intestinal mucosa, changes in gut permeability, and failure of intestinal defense mechanisms. These c...