U.S., June 13 -- ClinicalTrials.gov registry received information related to the study (NCT07017517) titled 'NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness' on May 26.
Brief Summary: The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM). It will also explore the role of NLRP3 inflammasome in the pathophysiology of CIM.
The main questions this study aims to answer are:
Is NLRP3 inflammasome activation associated with muscle atrophy through the upregulation of atrogenes?
Does physical therapy attenuate NLRP3 inflammasome activation in skeletal muscle, thereby contributing to the prevention or reduct...