Clinical Trial: Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)

U.S., July 30 -- ClinicalTrials.gov registry received information related to the study (NCT07091643) titled 'Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)' on July 22.

Brief Summary: Major depressive disorder (MDD) is associated with significant cognitive impairment throughout the life-course, which may progress toward MCI and dementia with age. Antidepressant medications are the first line of treatment; however, they fail to adequately address cognitive deficits and prevent relapse. Sustained cognitive impairment into euthymic periods may relate to underlying neurobiological changes, which could potentially be addressed through Cognitive Behavioural Therapy (CBT). Notably, CBT has been shown to improve...