U.S., Dec. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07271849) titled 'Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients' on Nov. 17.
Brief Summary: In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and cerebral damage in patients. Consequently, maintaining hemodynamic stability, ensuring adequate cerebral perfusion, and achieving controlled blood pressure during the perioperative period are critical factors influencing patient outcomes. Postoperatively, patients typically experience moderate to severe pain. S...