Clinical Trial: Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

U.S., March 28 -- ClinicalTrials.gov registry received information related to the study (NCT06899061) titled 'Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib' on March 21.

Brief Summary: A Phase I modular study to assess the effect of oral saruparib on other treatments in patients with advanced solid malignancies.

Study Start Date: March 24

Study Type: INTERVENTIONAL

Condition: Advanced Solid Malignancies

Intervention: DRUG: Saruparib

Module 1:

Period 2: participants will receive saruparib orally once daily from Day 1 to Day 9. On Day 5 saruparib will be administered orally in combination with the cocktail of substrates.

Period 3: participants will recei...