U.S., Jan. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07352917) titled 'Methotrexate for Severe Vulvar Lichen Sclerosus' on Dec. 19, 2025.
Brief Summary: Vulvar lichen sclerosus is a chronic inflammatory skin disease affecting the vulva and genital region, which may cause intense pruritus, pain, burning sensations, and progressive scarring. In severe cases, the disease may lead to significant anatomical changes, sexual dysfunction, and a reduction in quality of life.
First-line treatment for vulvar lichen sclerosus consists of high-potency topical corticosteroids. Although many patients experience symptom relief, a considerable number of women continue to have persistent symptoms or progressive anatomi...