U.S., Nov. 13 -- ClinicalTrials.gov registry received information related to the study (NCT07227064) titled 'Methadone in THA for Post-op Pain and Opioid Reduction' on Nov. 10.
Brief Summary: This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recover...