U.S., Jan. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07336095) titled 'Melatonin vs Midazolam in Children Undergoing Tonsillectomy' on Nov. 24, 2025.
Brief Summary: Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
Melatonin is a hormone secreted by the pineal gland. Melatonin is different from benzodiazepines and their derivatives in that it exerts a promoting effect on sleep by amplifying day/night differences in alertness and sleep quality and displaying a modest sleep-inducing effect, quite mild as compared to that seen with ben...