U.S., Jan. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07318974) titled 'Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve' on Dec. 21, 2025.
Brief Summary: Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction. Melatonin is a potent antioxidant that may protect developing eggs from oxidative stress. This randomized clinical trial aims to evaluate whether a 4-week course of oral melatonin therapy before egg retrieval can improve the quality of oocytes and embryos, and ultimately increase pregnancy rates for women with DOR undergoing Intracytoplasmic Sperm Inje...