U.S., March 14 -- ClinicalTrials.gov registry received information related to the study (NCT06875765) titled 'Long-term Longitudinal Imaging of Presynaptic Terminals in PD' on March 07.
Brief Summary: AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD.
STUDY DESIGN: We will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinica...