U.S., Jan. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07319104) titled 'Liquid Biopsy in Early Colorectal Lesions' on Dec. 02, 2025.
Brief Summary: Early colorectal cancer screening increasingly detects small superficial colonic lesions, but current diagnostic tools still struggle to distinguish benign from malignant lesions and to assess lymph node risk. As histology after resection has limited accuracy, many patients undergo unnecessary surgery.
Liquid biopsy, analyzing circulating biomarkers such as tumor DNA, extracellular vesicles, and nucleosomes, offers a non-invasive way to better classify these lesions. Emerging evidence suggests it may outperform current criteria for predicting lymph node invo...