Clinical Trial: Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window

U.S., May 24 -- ClinicalTrials.gov registry received information related to the study (NCT06987305) titled 'Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window' on May 07.

Brief Summary: This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human tenecteplase (rhTNK-tPA) in acute ischemic stroke patients with large vessel occlusion presenting 4.5-24 hours after last known well. The study will address two primary questions: 1) Whether rhTNK-tPA enhances pre-thrombectomy reperfusion rates and improves 90-day functional outcomes compared to placebo; 2) Whether rhTNK-tPA increases the risk of symptomatic intracranial hemorrhage and...