U.S., Feb. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07419685) titled 'Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste' on Feb. 12.
Brief Summary: This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices-one fluoride-free negative control, one positive control with 0.243% sodium fluoride, and one investigational dentifrice containing 0.243% sodium fluoride and 20% sodium bicarbonate. Healthy adult subjects wore a palatal acrylic appliance containing demineralized enamel specimens for three 9-day treatment periods, during which in vivo brushing/slu...