U.S., June 25 -- ClinicalTrials.gov registry received information related to the study (NCT07032857) titled 'Intestinal Permeability in Children With Autism Spectrum Disorder' on June 10.
Brief Summary: In recent years, increasing attention has been directed toward the role of the gut-brain axis in the pathogenesis of neurodevelopmental disorders, particularly Autism Spectrum Disorder (ASD). Among the multiple contributing factors, the integrity of the intestinal barrier appears to play a crucial role. Enhanced paracellular permeability ("leaky gut") may allow luminal antigens and microbial metabolites to translocate into the systemic circulation, triggering inflammatory responses that could impact neuropsychological functioning.
Several ...