U.S., March 21 -- ClinicalTrials.gov registry received information related to the study (NCT06885476) titled 'Infusion of Alloreactive nk Cells for Mrd-positive Aml Patients' on Jan. 22, 2021.
Brief Summary: This is a interventional, transplantation study. The procedure under study is the infusion of alloreactive NK cells in adult AML patients, eligible for ASCT, who achieved CR after conventional chemotherapy, but harbor MRD-positivity.
Haploidentical KIR-L mismatched donors will be included if present at least one allele mismatch at a class I locus among the following ones: HLA-C alleles with Asn77-Lys80, HLA-C alleles with Ser77-Asn80, HLA-Bw4 alleles. KIR-L mismatched donor alloreactive NK cell repertoire will be evaluated in order to...