Clinical Trial: Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

U.S., Oct. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07220265) titled 'Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers' on Oct. 20.

Brief Summary: The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygyous carriers of phenylketonuria (PKU). The main questions it aims to answer are:

* Do PKU carriers experience prolonged elevations in brain Phe levels following oral ingestion of dietary Phe?

* Do PKU carriers experience disruptions in cognitive functioning following oral ingestion of dietary Phe?

* Do PKU carriers experience atypical brain acti...