U.S., Jan. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07328594) titled 'Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking' on Dec. 30, 2025.
Brief Summary: Tobacco use is the leading cause of preventable death in the U.S., with 480,000 deaths per year and 7.7 million deaths globally. A major clinical symptom associated with abstinence from both licit and illicit drugs is insomnia, which is a clinically verified, major risk factor for relapse. Roughly half of the 40 million smokers in the U.S. attempt to quit annually, with very low rates of success. One major hurdle is poor sleep quality during abstinence. Compounding the problem is that some pharmaceuticals to help reduce smoking can incr...