U.S., Aug. 20 -- ClinicalTrials.gov registry received information related to the study (NCT07129473) titled 'Hyperemesis Gravidarum Risk Reduction With Metformin' on Aug. 07.
Brief Summary: The goal of this clinical trial is to evaluate whether daily oral metformin extended-release (metformin-XR), taken prior to pregnancy, can reduce the risk and severity of Hyperemesis Gravidarum (HG)-a severe nausea and vomiting condition in pregnancy-in individuals aged 18-49 who have experienced HG in a previous pregnancy and are trying to conceive.
The main questions it aims to answer are:
Is metformin-XR acceptable and well-tolerated when taken by non-pregnant individuals trying to conceive?
Does pre-pregnancy metformin-XR use reduce HG recurrence...